It is a first meeting between the two European giants since 2018, when the Blues were ousted 4-1 on aggregate in the last 16 thanks largely to the efforts of one Lionel Messi.
Chelsea head into the high-profile tie sitting 12th in the 36-team league table, having needed a second-half equaliser from Alejandro Garnacho to avoid losing to Qarabag in a 2-2 draw in Azerbaijan earlier this month.
They face another tough test against a Barcelona side who trail rivals Real Madrid by a point in the LaLiga title race after notching three successive wins since their Clasico defeat last month, brushing aside Athletic Club 4-0 at the weekend in their first game back at the renovated Camp Nou since May 2023.
Barcelona have the same record as Chelsea in the Champions League this season and sit one spot above them only by virtue of a slightly superior goal difference, having beaten Newcastle and thrashed Olympiacos but also lost to holders Paris Saint-Germain and needed to fight back three times in a thrilling 3-3 draw with Club Brugge last time out.
Date, kick-off time and venue
Chelsea vs Barcelona is scheduled for an 8pm GMT kick-off on Tuesday November 25, 2025.
The match will take place at Stamford Bridge in west London.
Where to watch Chelsea vs Barcelona
TV channel and live stream: In the UK, the game will be broadcast live on Amazon Prime Video. Coverage begins at 6:55pm GMT.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Chelsea correspondent Dom Smith at the Bridge.
Chelsea vs Barcelona team news
Back in action: Marcus Rashford will make the trip to Stamford Bridge having shaken off a bout of flu
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Moises Caicedo and Estevao Willian will both be pushing to return to the starting lineup after being left on the bench at Turf Moor.
Manchester United loanee Marcus Rashford is included in Barcelona’s travelling squad having resumed training in the aftermath of a bout of flu that forced him to miss the win over Athletic Club.
Raphinha and goalkeeper Joan Garcia both returned in that game, while Alejandro Balde went off at half-time as a precaution but does make the trip.
The visit to Chelsea comes too soon for Pedri, with Gavi and Marc-Andre ter Stegen remaining long-term absentees.
Chelsea vs Barcelona prediction
These two sides are separated by goal difference only in the Champions League and both now sit second in their respective domestic leagues, albeit with Barcelona having amassed eight more points having played one game extra.
Both teams have been curiously inconsistent in Europe so far despite their encouraging starts at home, needing to work hard earlier this month to avoid shock defeats by Qarabag and Brugge.
We anticipate a tense and cagey affair on Tuesday that likely ends all square.
Head to head (h2h) history and results
Chelsea lost 3-0 at the Camp Nou on their last outing against Barcelona in the last 16 of the Champions League in 2018, after drawing 1-1 at home.
They have not beaten the Catalans since the 2012 semi-finals, when they won 1-0 at home and drew 2-2 away before beating Bayern Munich in the showpiece.
Chelsea vs Barcelona match odds
Odds via Betfair (subject to change).
