The Bees will head into the new campaign without their long-time manager for the first time since 2018 after he left to join Tottenham. They also face losing some of their best players in Bryan Mbeumo and Yoane Wissa, both of whom have been linked with moves away from the club this summer.
It is a tough start for Brentford, who welcome Aston Villa to west London in their second game, before facing Chelsea, Manchester United, Man City and Liverpool before the end of October.
Brentford will be reunited with Frank at the Tottenham Hotspur Stadium on December 12, with Frank heading back to the Bees on December 30.
The season concludes away at Liverpool.
Brentford confirmed Premier League 2025/26 fixture list
16/08/2025 – 15:00 – Nottingham Forest (a)
23/08/2025 – 15:00 – Aston Villa (h)
30/08/2025 – 15:00 – Sunderland (a)
13/09/2025 – 15:00 – Chelsea (h)
20/09/2025 – 15:00 – Fulham (a)
27/09/2025 – 15:00 – Manchester United (h)
04/10/2025 – 15:00 – Manchester City (h)
18/10/2025 – 15:00 – West Ham United (a)
25/10/2025 – 15:00 – Liverpool (h)
01/11/2025 – 15:00 – Crystal Palace (a)
08/11/2025 – 15:00 – Newcastle United (h)
22/11/2025 – 15:00 – Brighton (a)
29/11/2025 – 15:00 – Burnley (h)
03/12/2025 – 20:00 – Arsenal (a)
06/12/2025 – 15:00 – Tottenham Hotspur (a)
13/12/2025 – 15:00 – Leeds United (h)
20/12/2025 – 15:00 – Wolverhampton (a)
27/12/2025 – 15:00 – A.F.C. Bournemouth (h)
30/12/2025 – 20:00 – Tottenham Hotspur (h)
03/01/2026 – 15:00 – Everton (a)
07/01/2026 – 20:00 – Sunderland (h)
17/01/2026 – 15:00 – Chelsea (a)
24/01/2026 – 15:00 – Nottingham Forest (h)
31/01/2026 – 15:00 – Aston Villa (a)
07/02/2026 – 15:00 – Newcastle United (a)
11/02/2026 – 20:00 – Arsenal (h)
21/02/2026 – 15:00 – Brighton (h)
28/02/2026 – 15:00 – Burnley (a)
04/03/2026 – 20:00 – A.F.C. Bournemouth (a)
14/03/2026 – 15:00 – Wolverhampton (h)
21/03/2026 – 15:00 – Leeds United (a)
11/04/2026 – 15:00 – Everton (h)
18/04/2026 – 15:00 – Fulham (h)
25/04/2026 – 15:00 – Manchester United (a)
02/05/2026 – 15:00 – West Ham United (h)
09/05/2026 – 15:00 – Manchester City (a)
17/05/2026 – 15:00 – Crystal Palace (h)
24/05/2026 – 16:00 – Liverpool (a)
