Police have set up a forensics tent on Balls Pond Road, near the junction of Mildmay Park, following the crash today (July 1) at 2.23pm.
Medics treated the man but he was pronounced dead at the scene.
Balls Pond Road has been closed both ways since between Southgate Road and Culford Road as investigations take place.
Four bus routes are being diverted from the area, the 30, 38, 56 and 141.
The Metropolitan Police has been contacted for more information.
A London Ambulance Service spokesperson said: “We were called today (Tuesday, July 1) at 2.32pm to reports of a road traffic incident in Balls Pond Road, Islington. We sent ambulance crews, an incident response officer, an advanced paramedic practitioner and members of our hazardous area response team (HART).
“We treated a man at the scene but sadly, despite our efforts, he was pronounced dead.”
