Adam Wharton withdrew with injury, while Bukayo Saka, Jude Bellingham, and Cole Palmer are all sidelined too.
That could therefore mean a more experimental line-up for the Three Lions, who are three wins from three in Group K.
They beat Albania 2-0 and Latvia 3-0 in their opening two games, before sneaking past today’s opposition 1-0 back in June.
A 3-1 defeat by Senegal followed, and Tuchel will be out for a strong response in the first game since that loss.
How to watch England vs Andorra
TV channel: ITV1 is the place to watch this one, with coverage to begin at 4pm BST ahead of a 5pm BST kick off from Villa Park.
Live stream: Viewers can also tune in via live stream on ITVX and the ITV website.
Live blog: You can follow all the action on Standard Sport’s live blog, with expert insight and analysis from Dom Smith.
