The incident happened in Balls Pond Road near the junction of Mildmay Park at around 2.30pm yesterday (July 1).
Officers and London Ambulance Service attended where a man in his 70s was treated.
The man later died from his injuries.
His next of kin have been informed and are being supported by specialist officers.
The driver of the lorry stopped at the scene and is helping the police with an investigation.
Detectives from the Serious Collision Investigation Unit are looking into how the crash in Dalston happened.
They have asked anyone who was in the area, witnessed the incident or captured it on camera to come forward using 101 or ‘X’ @MetCC and quoting CAD 5177/1JUL.
In a separate incident on the same morning, a woman in her 70s was also hit by a car nearby on Lower Clapton Road.
She was taken to hospital where she remains in a non-critical condition.
A spokesperson for Metropolitan Police said: “Police are appealing for witnesses and footage following a fatal collision in Islington.
“Officers were called to Balls Pond Road, N1 at 2.32pm on Tuesday, 1, July following reports that a pedestrian had been hit by a lorry.
“Met officers attended the scene alongside other emergency services. Sadly, despite the best efforts of medical staff, a man aged in his 70s died from his injuries.
“His next-of-kin have been informed and are currently being supported by specially trained officers. The driver of the lorry stopped at the scene and is assisting the police investigation.
“An investigation into the circumstances is under way by detectives from the Serious Collision Investigation Unit.
“They would like to hear from anyone who was in the area and witnessed this incident, or any road users or pedestrians who may have captured events on film.
“Anyone with information that could assist police is asked to call 101 or ‘X’ @MetCC and quote CAD 5177/1JUL.”
A London Ambulance Service spokesperson said: “We were called today (Tuesday, July 1) at 2.32pm to reports of a road traffic incident in Balls Pond Road, Islington.
“We sent ambulance crews, an incident response officer, an advanced paramedic practitioner and members of our hazardous area response team (HART).
“We treated a man at the scene but sadly, despite our efforts, he was pronounced dead.”
