Lola Bignel has been missing for three days since a report was first made on Monday (June 30).
She was spotted the day after in the Heath Road area of Dartford, with an image showing she appears to have dyed her hair black instead of her usual brown hair.
The 16-year-old is described as around 5ft 5in and of a slim build with blue eyes.
Lola has links to Bexleyheath as well as Margate and around east Kent.
Anyone who has seen Lola or who has critical information is asked to call 999 quoting reference 30-0330, for any other information that could help, call 101.