There were reports of a fight in Lower Clapton Road on Saturday (June 28) at 12.56am between two men.
Medics treated a man, 32, at the scene before taking him to hospital, where he remains with serious and possible life-changing injuries.
Officers are hoping to speak to Christopher Richards, 32, of South Ockendon in Thurrock, in relation to the assault.
Richards is known to have links to Hackney.
Police hope to find Christopher Richards (Image: Metropolitan Police) He is described to have a medium and broad build, with dark brown hair.
An image has been released of Richards by the Metropolitan Police.
Anyone with information on his whereabouts or who could help the investigation is asked to contact police on 101 quoting CAD 409/28JUN25.
Alternatively, contact Crimestoppers anonymously on 0800 555 111.