Arguably the pick of the last-16 ties remains finely poised after a fascinating first-leg battle at the Santiago Bernabeu last week, which the holders won 2-1 thanks to a stylish second-half winner from Brahim Diaz.
That goal came after Rodrygo had given Los Blancos the perfect start with a dazzling strike inside just four minutes, before Julian Alvarez later restored parity with a rocket of his own just past the half-hour mark.
Real Madrid have since leapfrogged Atletico into second spot in a fiercely contested LaLiga title battle after quick-fire first-half goals from star forwards Kylian Mbappe and Vinicius Jr were enough to see off Rayo Vallecano 2-1 at home on Sunday.
Atleti, meanwhile, missed the chance to go top above Barcelona after they capitulated in the final minutes to lose by the same scoreline away at Getafe, with Alexander Sorloth’s penalty followed by a red card for Angel Correa and a dramatic late brace from Mauro Arambarri.
How to watch Atletico vs Real Madrid
TV channel: In the UK, the latest high-profile instalment of the Madrid derby is being shown live on TNT Sports 3. Coverage begins at 7:30pm GMT ahead of an 8pm kick-off at Metropolitano Stadium.
Live stream: TNT Sports subscribers can also catch the game live online via the Discovery+ website and app.
Live blog: Follow the action as it happens with Standard Sport’s live match blog.