While Ruben Amorim’s side have impressed in recent games against Liverpool and Arsenal, it remains to be seen if they can produce the same kind of display in a game that perhaps does not excite the players quite as much.
That has long been a criticism of this inconsistent United side, though they will fancy their chances of starting to turn that around when they host a Saints team in dire form.
Here’s everything you need to know about where to watch the game.
How to watch Manchester United vs Southampton
TV channel: In the UK, the game will be televised live on TNT Sports 1 and TNT Sports Ultimate. Coverage starts at 7pm GMT ahead of an 8pm kick-off.
Live stream: Fans can catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.