The Gunners are looking for a response after their 2-0 defeat against Newcastle in the first leg of their Carabao Cup semi-final on Tuesday.
The FA Cup is the major one trophy Mikel Arteta has lifted while in charge of Arsenal and he is seeking more trophies.
Holders United, meanwhile, raised their game against Liverpool last weekend and Ruben Amorim would love a good cup run to raise confidence.
Here’s everything you need to know about where to watch the game…
How to watch Arsenal vs Manchester United
TV channel: The game will be broadcast on BBC One. Coverage starts at 2.35pm GMT ahead of an 8pm kick-off.
Live stream: Subscribers will be able to watch on a live stream via the BBC Sport website and the BBC iPlayer, which are both free with a subscription.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog!
