Arne Slot’s side will be top at Christmas if they win, while Spurs will be looking to build on their dramatic 4-3 Carabao Cup win against Manchester United on Thursday.
Spurs could be in the bottom half of the table at Christmas if they fail to win.
Here’s everything you need to know about the game…
Date, kick-off time and venue
The Tottenham Hotspur Stadium will host.
Where to watch Tottenham vs Liverpool
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go app.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog!
Tottenham vs Liverpool team news
Ange Postecoglou is missing some key Tottenham players
AP
Ben Davies, Micky van de Ven, Cristian Romero, Richarlison, Wilson Odobert and Guglielmo Vicario are all expected to miss out through injury. Rodrigo Bentancur is suspended.
Tottenham vs Liverpool prediction
Spurs have raised their game in some of the bigger matches this season but Liverpool look a step above.
Head to head (h2h) history and results
Tottenham vs Liverpool latest odds
Odds via Betfair and subject to change.